• Latest
New Study Provides First Evidence of African Children with Severe Malaria Experiencing Partial Resistance to World’s Most Powerful Malaria Drug

New Study Provides First Evidence of African Children with Severe Malaria Experiencing Partial Resistance to World’s Most Powerful Malaria Drug

November 14, 2024

Kahemba Babi Declares Mayoral Bid for Kampala Central Division

July 10, 2025
17 Injured as Baby Coach Bus Crashes into Trailer in Nakasongola

17 Injured as Baby Coach Bus Crashes into Trailer in Nakasongola

July 10, 2025
VINAStech Advert
Isingiro South MP Candidates Set To Resume Campaigns Following Mediation with NRM Electoral Commission Chief

Isingiro South MP Candidates Set To Resume Campaigns Following Mediation with NRM Electoral Commission Chief

July 10, 2025

Dokolo District Schools Inspector On the Spot Over Forgery of Academic Papers

July 10, 2025
Breakthrough in Malaria Treatment for Newborns and Infants

Breakthrough in Malaria Treatment for Newborns and Infants

July 9, 2025
UEDCL Marks 100 Days of Progress After Taking Over Electricity Distribution

UEDCL Marks 100 Days of Progress After Taking Over Electricity Distribution

July 9, 2025
Refugee Family Appeals for UGX 80m to Save Baby With Heart Condition

Refugee Family Appeals for UGX 80m to Save Baby With Heart Condition

July 9, 2025
Baby Coach Bus Involved in Crash

Baby Coach Bus Involved in Crash

July 9, 2025
Rising Murder Fears in Ishaka-Bushenyi as Two Bodies Are Discovered in a Day

Father Killed in Domestic Violence in Kwania District

July 9, 2025
Kyarampe Vows Loyalty, Calls for Unity in Heated Mitooma NRM Primaries

Kyarampe Vows Loyalty, Calls for Unity in Heated Mitooma NRM Primaries

July 9, 2025
Guma Samuel Urges Journalists to Uphold Ethics and Purpose in the Age of New Media

Guma Samuel Urges Journalists to Uphold Ethics and Purpose in the Age of New Media

July 8, 2025

Resist Pressure to Declare Different Candidates, Catholic Priest Urges EC

July 8, 2025
  • About Us
  • Internship
  • Contact Us
Thursday, July 10, 2025
Parrots Media
No Result
View All Result
  • Login
  • News

    Dokolo District Schools Inspector On the Spot Over Forgery of Academic Papers

    UEDCL Marks 100 Days of Progress After Taking Over Electricity Distribution

    UEDCL Marks 100 Days of Progress After Taking Over Electricity Distribution

    Baby Coach Bus Involved in Crash

    Baby Coach Bus Involved in Crash

    Rising Murder Fears in Ishaka-Bushenyi as Two Bodies Are Discovered in a Day

    Father Killed in Domestic Violence in Kwania District

    Resist Pressure to Declare Different Candidates, Catholic Priest Urges EC

    Kyarampe Rides Wave of Support in Mitooma Woman MP NRM Primary Race

    Trending Tags

  • Climate Change
  • Business
  • Science and Technology
  • Sports and Entertainment
  • Business
  • Others
    • Education
    • Lifestyle
    • Religion
    • Opinions
  • News

    Dokolo District Schools Inspector On the Spot Over Forgery of Academic Papers

    UEDCL Marks 100 Days of Progress After Taking Over Electricity Distribution

    UEDCL Marks 100 Days of Progress After Taking Over Electricity Distribution

    Baby Coach Bus Involved in Crash

    Baby Coach Bus Involved in Crash

    Rising Murder Fears in Ishaka-Bushenyi as Two Bodies Are Discovered in a Day

    Father Killed in Domestic Violence in Kwania District

    Resist Pressure to Declare Different Candidates, Catholic Priest Urges EC

    Kyarampe Rides Wave of Support in Mitooma Woman MP NRM Primary Race

    Trending Tags

  • Climate Change
  • Business
  • Science and Technology
  • Sports and Entertainment
  • Business
  • Others
    • Education
    • Lifestyle
    • Religion
    • Opinions
No Result
View All Result
Parrots Media
No Result
View All Result
Home Health

New Study Provides First Evidence of African Children with Severe Malaria Experiencing Partial Resistance to World’s Most Powerful Malaria Drug

Gonzaga M Stephen by Gonzaga M Stephen
November 14, 2024
in RELIGION
0
New Study Provides First Evidence of African Children with Severe Malaria Experiencing Partial Resistance to World’s Most Powerful Malaria Drug
0
SHARES
0
VIEWS
Share on FacebookShare on X

By Our Reporter,

NEW ORLEANS

READ ALSO

Police Urge Vigilance Amid Ongoing Terror Threats

Journalists blocked from Martyrs Day Venue

A new study from Uganda provides the first evidence to date that resistance to a lifesaving malaria drug may be emerging in the group of patients that accounts for most of the world’s malaria deaths: young African children suffering from serious infections. The study, presented today at the Annual Meeting of the American Society of Tropical Medicine and Hygiene and published in the Journal of the American Medical Association (JAMA), documented partial resistance to the malaria drug artemisinin in 11 of 100 children, ages 6 months to 12 years, who were being treated for “complicated” malaria, that is, malaria with signs of severe disease caused by the malaria parasite Plasmodium falciparum.

ADVERTISEMENT

Also, 10 patients who were thought to have been cured suffered a repeat malaria attack within 28 days from the same strain of malaria that caused the original infection, suggesting that the initial treatment did not fully kill the infecting parasites.

https://eadmission.ciu.ac.ug/
ADVERT: Double your impact, and halve the cost! Get your #MBA for 50% off and become a transformative #leader with the vision to shape the future of business. #Apply #today at https://eadmission.ciu.ac.ug/ and invest in your future! #CIU #Innovate #Lead

“This is the first study from Africa showing that children with malaria and clear signs of severe disease are experiencing at least partial resistance to artemisinin,” said Chandy John, MD, MS, director of the Indiana University School of Medicine Ryan White Center for Infectious Diseases and Global Health, who is a co-author of the study along with colleagues Ruth Namazzi and Robert Opoka from Makerere University in Kampala in Uganda, Ryan Henrici from University of Pennsylvania, and Colin Sutherland from London School of Hygiene & Tropical Medicine.

John, who is a former ASTMH president said, “It’s also the first study showing a high rate of African children with severe malaria experiencing a subsequent malaria episode with the same strain within 28 days of standard treatment with artesunate, a derivative of artemisinin, and an artemisinin combination therapy (ACT).”

The arrival of artemisinin therapies some 20 years ago was a major advance in the global fight against malaria due to their power to rapidly cure infections — and because malaria parasites had developed resistance to other drugs. In 2008, there were reports from Cambodia noting partial resistance to artemisinin. By 2013 there was evidence that in some patients, the drug was completely failing. In the last few years, there has been increasing evidence that artemisinin resistance has now spread from that region into East Africa. The prospect of artemisinin losing its efficacy is particularly alarming for Africa and especially for African children. The region accounts for 95% of the 608,000 people who die from malaria each year and a large majority of malaria deaths in Africa are children under 5.

While all of the children in the study eventually recovered, 10 of them were infected with malaria parasites that harbor genetic mutations that have been linked to artemisinin-resistance in Southeast Asia. The study noted that while these mutations have been documented in Africa in less severe cases, this was the first time they have been seen in parasites that were causing complicated malaria in hospitalized African children. The term “complicated” malaria is used to define cases where the disease is at risk of causing potentially life-threatening complications, like severe anemia or brain-related problems known as cerebral malaria.

Stebbo Smart Pro Advert

John said that researchers classified patients as suffering from partial resistance based on the World Health Organization’s defined half-life cutoff for parasite clearance of more than five hours, meaning requiring more than five hours to reduce a patient’s parasite burden by 50%. Two children required longer than the standard maximum of three days of artesunate therapy because they failed to clear their parasites with three days of therapy. He said longer treatment times increase the risk of poor outcomes. Also, he said that in Southeast Asia, the path to broadly resistant malaria parasites started with evidence of partial artemisinin resistance, and the concern is that pattern will be repeated in sub-Saharan Africa.

The Ugandan children in the study received what is considered to be the gold standard for treating complicated malaria infections: an intravenous infusion of artesunate followed by oral treatment with an ACT that combines another derivative of artemisinin, a drug called artemether, with the malaria drug lumefantrine.

John said the relatively high number of recurrent cases raises concerns that the efficacy of lumefantrine also may be declining. The drug is paired with artemether to make it harder for parasites to develop artemisinin resistance and also because lumefantrine stays in the body longer than artemether. Therefore, it can kill any remaining parasites not cleared by the shorter-acting artemisinin.

John said the study emerged from ongoing work in Uganda that is investigating outcomes of children who experience episodes of severe malaria. He said researchers pivoted to a focus on drug resistance because they noticed some children appeared to be slower to respond to the infusion of artesunate followed by an oral ACT.

“The fact that we started seeing evidence of drug resistance before we even started specifically looking for it is a troubling sign,” John said. “We were further surprised that, after we turned our focus to resistance, we also ended up finding patients who had recurrence after we thought they had been cured.”

Tags: Anti-malaria DrugsMalaria Control ProgramPrevalence of Malaria in uganda

Related Posts

Police Urge Vigilance Amid Ongoing Terror Threats
Religion

Police Urge Vigilance Amid Ongoing Terror Threats

June 6, 2025
Journalists blocked from Martyrs Day Venue
Religion

Journalists blocked from Martyrs Day Venue

June 3, 2025
News

Malawian, Tanzanian Students Jet In for Uganda Martyrs Essay Awards

June 2, 2025
RELIGION

UPC Urges Reflection and Reform Ahead of Uganda Martyrs Day

May 28, 2025
News

Kasujja Warns Against Secularism as UMU Trains Chaplains to Tackle Youth Crisis

May 26, 2025
Uganda Martyrs Essay Competition Expands Across East Africa
RELIGION

Uganda Martyrs Essay Competition Expands Across East Africa

May 23, 2025
Next Post

Minister Kataha Urges Residents to Support Government Programmes for Socio-economic Change

POPULAR NEWS

Catholic Priest Speaks Out Against Museveni and Son’s Leadership

Catholic Priest Speaks Out Against Museveni and Son’s Leadership

February 16, 2025

Former IGP Okoth Ogola Dies

February 14, 2025

A Love Beyond Distance: A review of Leonard Kamugisha Akida’s poetic tribute on valentine’s day

February 14, 2025

Besigye Sends Easter Message from Luzira Prison as Archbishop Kazimba Urges for Release of Political Prisoners

April 18, 2025
Brutality at KIU: Students Assaulted by Officials at Examination Hall

KIU Loses Bid to Block Payment of Shillings 46.8 Billion to Housing Finance Bank

March 12, 2025

EDITOR'S PICK

Kahonda, Bashiisha Under Fire as NRM Launches New Base in Mitooma

Kahonda, Bashiisha Under Fire as NRM Launches New Base in Mitooma

July 6, 2025
Kenyan driver brutally shot dead in South Sudan

Kenyan driver brutally shot dead in South Sudan

September 24, 2023
Koboko hospital ambulance intercepted with smuggled cigarettes

Koboko hospital ambulance intercepted with smuggled cigarettes

September 10, 2023

Man chops off wife’s legs in FortPortal

September 22, 2021
VINAStech advert VINAStech advert VINAStech advert
ADVERTISEMENT

About

Parrots Media

A Public Relations and Media Services Company registered and licensed to operate in Uganda and the Great Lakes Region.

Follow us

Categories

  • Business
  • BUSINESS REPORTS
  • CLIMATE ACTION REPORTS
  • Climate Change
  • COMMUNITY REPORTS
  • Education
  • Entertainment
  • FEATURES
  • Health
  • Lifestyle
  • News
  • News
  • Obituary
  • OBITUARY
  • Opinions
  • RELIGION
  • Religion
  • Science and Technology
  • Sports
  • Sports and Entertainment
  • TOURISM

Recent Updates

  • Kahemba Babi Declares Mayoral Bid for Kampala Central Division
  • 17 Injured as Baby Coach Bus Crashes into Trailer in Nakasongola
  • Isingiro South MP Candidates Set To Resume Campaigns Following Mediation with NRM Electoral Commission Chief
  • Dokolo District Schools Inspector On the Spot Over Forgery of Academic Papers
July 2025
M T W T F S S
 123456
78910111213
14151617181920
21222324252627
28293031  
« Jun    
  • About Us
  • Internship
  • Contact Us

© 2025 Parrots Media | Website Designed and Maintained by VINAStech

No Result
View All Result
  • Parrots Media
  • News
  • Business
  • Science and Technology
  • Sports and Entertainment
  • Lifestyle
  • Others
    • Climate Change
    • Education
    • Religion
    • Opinions

© 2025 Parrots Media | Website Designed and Maintained by VINAStech

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In

You cannot copy content of this page